Why have we become a acne-fighting nation?
If you want to talk about acne, you have to start with it.
Acne, the scientific name [acne cuo sore], is a very typical and common
chronic skin disease (please note that I used
disease Two words). Acne attacks are mostly caused by inflammation of the sebaceous glands. The grades are divided into whiteheads/blackheads (both are acne), papules, pustules, nodules and cysts. As the strokes increase, the skin damage and inflammation increase. It's getting worse. According to the latest edition of the "Chinese Acne Diagnosis and Treatment Guidelines 2019 Revised Edition" in 2019,
acne is divided into 3 degrees and 4 levels.
In our previous article, we also systematically explained how to effectively remove blackheads (that is, open acne), forget You can go back and review it again.
Which areas are more prone to acne?
A fan asked in the group that people have sebaceous glands all over their body. Why is it that only the face and back are most prone to acne?
This is a good question.
There are three types of human sebaceous glands. The first is the sebaceous glands in the
head, beard, eyebrows, etc. These sebaceous glands have small glands, accompanied by protruding hairs on the body. The second category is
[cui, read four tones] fur fat glands except for hair, beard and eyebrows. These glands are relatively larger. The third type is called
hair follicle sebaceous glands. The glands are thick, thick and branched, and the hair is almost invisible from the outside.
The third category is the hair follicle sebaceous glands that give us the most headaches. These glands secrete the most oil, most of which are distributed on the face, back and chest of the human body. This kind of open sebaceous duct is very easy to be filled with oil and cell debris, thus becoming a hotbed for Propionibacterium acnes.
Picture modified on the classification and treatment of acne
acne is high on the face and back
What factors do acne hook up with?
The wildfire is endless, and the spring breeze blows again.
The use of this poem to describe repeated acne situations cannot be more accurate. When thinking of acne, most people think of what methods can be used to get rid of acne. I learned a lot of acne products and methods in the small red book, such as salicylic acid, bansai, tea tree oil, sulfur, red and blue light, and even each. Kind of acne needles. But I never thought that
the majority of people have a high incidence of acne, why not just kill it in the cradle, there is no need to make it so heroic.
Receptors that regulate the function of sebaceous glands can be divided into six categories. Among them, the representative ones are histamine-regulated histamine receptors, androgen-regulated androgen receptors, and corticotropin releasing hormone (CRH) and other neuropeptide receptors.
The most widely known of these factors is naturally androgens,Dihydrotestosterone (DHT) happens to be the most active form of androgen, which is produced by the metabolism of testosterone through 5α-reductase. Where is this 5α-reductase most distributed? Yes, they are concentrated on the
scalp and face.
Finasteride, the most effective drug for the treatment of male alopecia at present, uses the principle of specifically inhibiting 5α-reductase.
To put it a bit further, more than 70 years ago, scientists occasionally discovered that men who had been castrated would never lose their hair in their lives. This is the first confirmation The relationship between androgens and hair loss. So theoretically speaking, the eunuchs in the TV series should not have bald heads. Regarding the content of hair loss, we will specifically discuss it in detail in the following hair-producing articles.
Whether it is men, women or children, androgens play an important role in different stages of your life. Babies born one week ago often have [neonatal acne], which is due to the high intake of androgens from breast milk (for the child's own level), plus its own synthesis and the androgens from the mother before birth. At this time, high-yield sebum broke out and Malassezia multiplyed, causing acne and seborrheic dermatitis.
Not to mention puberty, all of you here are from past people. Adult women taking birth control pills (for example, containing progesterone), contraceptive devices, or androgen changes before menstruation can cause changes in hormone levels. Therefore,
a woman's life is really not easy.
Stress itself is not a bad thing, but
stress makes the human body produce a glucocorticoid called [cortisol], commonly known as "stress hormone" . Similar to androgens, cortisol sends out signals that stimulate the sebaceous glands to release oil, leading to increased skin inflammation.
When it comes to the relationship between histamine and acne, some people may be confused, but when it comes to mites, everyone knows that acne can be caused.
The mites themselves do not cause acne, but may cause skin allergies in some people. Allergies produce a lot of histamine, which is the real cause of acne outbreaks. Similarly, some people
sun exposure can also cause acne, which is also a chain reaction of
skin allergies caused by ultraviolet rays.
The relationship between these three factors and acne is not the focus of this article. I will talk about it in [Skin care products and acne] The more system.
Why should we cure acne from diet?
Only three of the above six factors are mentioned, and the three in the red box on the left are not mentioned.
Don't be a fan, you are not afraid of being late for a good meal.
Let me talk about sugar first.
Many popular science mentions that
people who love acne try to avoid the intake of milk and sugar, which can greatly reduce the chance of acne. But everyone may know it, but don’t know why, so I have to talk about insulin growth factor IGF-1.
Everyone should be familiar with the word
[Insulin], it can
regulate human blood sugar levels. When the sugar intake is too much, the secretion of insulin will be accelerated. Together with it, there is the insulin growth factor IGF-1. The increase of IGF-1 will not only stimulate the secretion of androgens, but also activate the mTOR and FOXP1 signaling pathways, further stimulate the sebaceous gland cells to secrete lipids and accelerate the inflammatory response. Acne happened so unsurprisingly.
Except for sugar, the principle of milk-induced acne is similar. Although milk does not contain sugar, the Lun’s family directly contains a relatively large amount of IGF-1, which saves time and effort. There is no need to bother the body to transform. The IGF that enters the body can directly start working, which can be said to save time and effort. I wrote a popular science article on the efficacy of camel milk before. It mentioned that the content of IGF in camel milk is higher than that in cow's milk. If you are a person who loves acne, you should avoid it. Don't get caught by some unscrupulous merchants. Blinded.
Let's talk about fatty acids. Sebum is mainly composed of triglycerides, glycerides, squalene and other cholesterols. Among them, the content of triglycerides is the highest, which can account for about 50%. Triglycerides can be decomposed by bacteria such as Propionibacterium acnes and generate a large amount of free saturated fatty acids.
The most easily overlooked problem lies here.
Palmitic acid is the most typical saturated fatty acid, which can further generate hexadecenoic acid and stimulate hair follicle keratinization (I have mentioned it here, and the next article will focus on keratinization). The more saturated fatty acids we consume daily, the more saturated fatty acids represented by palmitic acid in sebum. This type of food is the beef, sheep and pork we often eat.
So, we can break the acne into several key points. First, it is a chronic inflammation of the skin; secondly, it is regulated by various receptors, such as IGF-1 receptor; and finally,
the stroke of acne is related to the proportion of sebum composition. Having found these three points, we can pay attention to the factors related to these three points from the diet.
Since it is mentioned above, let's take a look at which foods are prone to acne?
Which foods are most likely to cause acne
There are several types of foods that have actually been charged with "acne-causing".
01 High GI food, corresponding to the IGF-1 receptor mentioned above
The name of GI is [Glycemic Index], which can be easily understood as food After eating, it can be quickly converted into sugar. According to the GI ratio, foods can be divided into three categories. Low GI foods (GI
Which foods are high GI? You can understand them as high-sugar and refined carbohydrate foods. This may belong to the kindergarten class "Baby The knowledge points in "Child Science Enlightenment" even my home.
The picture comes from HomeTest Ding Ma Family Laboratory
02 Milk, corresponding to the IGF-1 receiver above Body
The reasons are explained above, so I don’t have to spend much time here.
Remember whether it is skimmed milk or whole milk, it is an acne-causing artifact. Of course if Sugar is also added to the milk, wow ha ha ha ha ha, congratulations, you are the last step away from getting acne.
03 High saturated fat, corresponding to the above The composition of sebum
The reason is also explained above. The more saturated fat is consumed, the composition of sebum will eventually change. This is why people who love meat always have shiny faces every day The reason.
are good for reducing acne?
01 low blood sugar diet (Low GI diet)
Studies have shown that adhering to a low-glycemic diet and a balanced diet for 12 weeks can effectively reduce the level of IGF-1 in the blood, the activity of IGF-1 and the Bioavailability will be significantly reduced, free androgen levels in the body and the number of skin lesions will be reduced.
02 Unsaturated fatty acids
Acne itself is a kind of chronic inflammation,
Therefore, if there are foods or ingredients that can inhibit the inflammatory response, it can reduce the occurrence of acne. Such a good job must of course be entrusted to our elderly Friends, omega-3 unsaturated fatty acids (n3-PUFA), which are familiar DHA and EPA.
In our previous articles, we mentioned the benefits of DHA and EPA on the human body several times. Among them, the focus is on the anti-inflammatory effects of DHA (the portal-fish oil reduces allergies and asthma attacks). DHA/EPA is similar in structure to the pro-inflammatory factor precursor arachidonic acid [AA], so it can be compared with arachidonic acid. The enoic acid competes with its receptor to reduce the synthesis of leukotriene [LT] from the root. DHA/EPA can also form retinoids and protectins, thereby further reducing the outbreak of inflammation.Pictures from HomeTest Ding Ma Home laboratory
Little knowledge about leukotrienes
Although they are also long-chain unsaturated fatty acids, leukotrienes are not It is a member of the Justice Avengers Alliance. Its physiological activity is extremely strong, and it is hundreds or even thousands of times more sensitive than the histamine-histamine receptor allergy mentioned above.
It is a key factor for many diseases such as rhinitis and skin inflammation. Secondly, n3-PUFA food can significantly inhibit the expression of interleukins IL-1, IL-6 and IL-8 and other inflammatory factors. Interleukins are related to the hyperkeratinization of hair follicle mouth keratinocytes. The direct benefits of inhibiting interleukins can inhibit the formation of acne and delay the process of acne. It is worth noting that the effect of n6-PUFA is not necessarily.
Therefore, as long as it contains n3 unsaturated fatty acids (DHA, EPA, it can beIt is regarded as an effective [anti-inflammatory] food. For example, deep-sea fish (portal-which fish contains the most DHA) or additional DHA preparations (portal-how to eat DHA for different people);
03 Rough processed foods
If you want to eat, the coarser the food, the better, this is very scientific.
The degree of food processing directly determines its glycemic index. Just a few days ago, an article published in Diabetes Care, a top diabetes care magazine, deeply supports this view.The picture comes from the Internet.
The experimenters recruited 15 type II diabetic patients, divided foods with different grinding degrees and particle sizes into four groups, and randomly arranged volunteers to eat them. Finally, by testing the blood glucose changes of each person in different time periods, we can monitor the impact of different foods on blood glucose. The results show that the larger the food particles and the fewer
processing links, the smaller the impact on blood sugar. For processed grains, the GI index and the effect on blood sugar are likely to be doubled.
We will educate our children to eat more whole grains. The coarse grains here should not only include whole grains that taste not good, but also include Processing methods.
What other common sense do you need to know
Eating spicy food can cause acne?
There is no conclusive evidence that spicy and acne have any relationship.
But many people have questions, why after eating hot pot the day before, there will be a few acne protests the next day. Please start to recall with "technical content", what kind of oil is the base of Chongqing old hot pot you eat? Did you solve a few problems with your brain? Did you finish the snack halfway and add sesame sauce twice? Have you happily drank two or three buckets of 5-liter Sprite Cola Arctic Ocean? After eating, I finished all the free watermelon yogurt ice cream delivered by the waiter? Also known as xxx, CD Action!
With our [horizontal] way of eating, let alone acne on the face, acne on the scalp is a probation.
IGF and androgen, which one contributes more to acne?
This is a question that can be answered.
For most adults, in order to maintain all aspects of the body's functions, the androgen levels in the body will always be maintained at a
high level (regardless of male and female), but No acne. When the IGF level in the serum increases, acne will break out on a large scale. Many clinical trials have shown that in many people with severe acne, androgen levels are basically the same as normal people, and the concentration of IGF-1 in hair follicles and sebaceous glands in the blood is many times higher than normal people.
Do you have to eat less foods that are prone to acne?
According to our intestinal bacteria test, for people who are accustomed to high carbohydrate or high saturated fat, the level of Bacteroides in their bodies is much higher than that of vegetarians. These Bacteroides like to eat Carbohydrate foods break down saturated fat. If your eating habits are already this way and there are no skin problems, don’t panic. If acne breaks out for a period of time, you can consider whether certain ingredients are suddenly added to the diet, and avoid it at this time.
Everyone has heard that a lack of vitamin B can cause chronic skin diseases such as dermatitis, but few people may know that
excessive intake of vitamin B12 can cause acne outbreaks. Too much is too late. This is the truth.
Nothing can be done overnight, it's the same reason that you can grow beans and get beans. Not paying attention day after day makes you "unbeautiful" today.
HomeTest Family Laboratory: The acne you care most about, and the food you can’t quit